Factory reset worked for me on my s10. Downloaded Samsung Smart Switch to my laptop. Backed up all the data from the phone using USB cable. Factory reset the phone. Uploaded data from laptop back to the phone. No battery drain at all now. Not sure why this works but it did for me.
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I have the same issue on my s10. In airplane mode and medium power saver and I'm losing around 30% overnight. Never had this problem on my s7, 8 or 9. I'd lose maybe 2 or 3% overnight using same method.
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